A Herxheimer Reaction, or more commonly called a herx, is short for Jarisch-Herxheimer Reaction. The reaction was first observed by Adolf Jarisch and Karl Herxheimer when syphilis (another bacteria which is a spirochete) was treated with penicillin. This causes a systemic inflammatory response, caused by endotoxins released by the dying bacteria. The signs and symptoms of a Herx resemble bacterial sepsis. In layman’s terms, that means feeling worse before feeling better.

Individuals going through a herx reaction will experience a flare up of current, old and even new Lyme symptoms, along with a general inflammatory response. A general inflammatory response includes fever & chills, anxiety, nausea, pain, headaches, debilitating fatigue and more. The intensity of the Herx is an indication of the severity of the inflammation. Therefore you are likely to experience stronger herxes early in your treatment. It’s often described as the worst hangover of your life, but it does get easier with time!

Herx reactions are usually not life-threatening, but it is wise to take things slowly. A herx reaction is also self-limiting, which means that it will eventually run its course. It’s an unavoidable part of treating Lyme, but that doesn’t mean there aren’t things we can do to help our bodies deal with it. Enhancing our detox pathways is the most effective way to deal with a herx.